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NSF awards Emory's Center for Selective C-H Functionalization $20 million

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"We’ve developed advanced catalysts that allow us to control which carbon-hydrogen bond within a molecule will react and when," says Huw Davies, director of the Center for Selective C-H Functionalization. (Graphic/photo by Stephen Nowland and Dan Morton)

The National Science Foundation has awarded another $20 million to Emory University’s Center for Selective C-H Functionalization, to fund the next phase of a global effort to revolutionize the field of organic synthesis.

“Our center is at the forefront of a major shift in the way that we do chemistry,” says Huw Davies, professor of chemistry at Emory and the director of the Center for Selective C-H Functionalization (CCHF). “This shift holds great promise for creating new pathways for drug discovery and the production of new materials to benefit everything from agriculture to electronics.”

The CCHF began as an NSF Center for Chemical Innovation in 2009, with a seed grant of $1.5 million and four collaborating universities. In 2012, the NSF awarded the CCHF its first $20 million, enabling it to grow to encompass 16 U.S. institutions and seven industrial affiliates, including six major pharmaceutical companies and one of the largest U.S. chemical suppliers. The center also built global connections with major players in C-H functionalization in Japan, South Korea and the U.K.  

The CCHF has led the way for explosive growth in the field of C-H functionalization, publishing more than 200 papers on the topic through its collaborators. It has developed dozens of new catalysts for C-H functionalization, including four major classes from the Huw Davies group.

“The past five years we’ve developed the fundamentals for C-H functionalization and documented that the concept is viable,” Davies says. “Now we’re ideally positioned to maximize the further development of this chemistry and move forward to apply it.”

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